South Panola steamrolled its way to the Class 6A state title in 2010 and became the first and only national champion from Mississippi. How South Panola did it was pretty remarkable.
They trounced Meridian in the state championship game and were at No. 2 in the national rankings for one week before No. 1 team Euless (Texas) Trinity High lost in the state championship game, and South Panola moved up.
South Panola only gave up more than 13 points in a game once in 2010, in a 65-35 win over Georgia powerhouse Colquitt County in the second game of the season, and averaged 48.5 points per game.
Running back Qyen Griffin had one of the all-time great seasons in Mississippi history, rushing for 2,670 yards and 37 touchdowns, but remarkably, no player from South Panola's national title team made it to the NFL.